國家衛生研究院 NHRI:Item 3990099045/14910

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Title:	Re-examination of the risk of autoimmune diseases after dengue virus infection: A population-based cohort study
Authors:	Shih, HI;Chi, CY;Tsai, PF;Wang, YP;Chien, YW
Contributors:	National Mosquito-Borne Diseases Control Research Center
Abstract:	Author summaryDengue fever is a mosquito-borne tropical disease caused by the dengue virus. Antibodies produced during dengue infection can cross-react with several self-antigens to the tissues of the body and contribute to thrombocytopenia, coagulopathy, and vascular leakage in severe dengue. Autoimmunity might occur after dengue infection and cause some autoimmune diseases. Previous studies suggested some autoimmune diseases might be associated with dengue infection. Contrary to previous studies, our findings showed that dengue was associated with an increased short-term risk of a rare complication, autoimmune encephalomyelitis, but not associated with other autoimmune diseases. Previous studies suggested that dengue was associated with an increased risk of several autoimmune diseases. However, this association still needs to be explored due to the limitations of these studies. A population-based cohort study was conducted using national health databases in Taiwan and included 63,814 newly diagnosed, laboratory-confirmed dengue patients between 2002 and 2015 and 1:4 controls (n = 255,256) matched by age, sex, area of residence and symptom onset time. Multivariate Cox proportional hazard regression models were used to investigate the risk of autoimmune diseases after dengue infection. Dengue patients had a slightly higher risk of overall autoimmune diseases than non-dengue controls (aHR 1.16; P = 0.0002). Stratified analyses by specific autoimmune diseases showed that only autoimmune encephalomyelitis remained statistically significant after Bonferroni correction for multiple testing (aHR 2.72; P < 0.0001). Sixteen (0.025%) dengue patients and no (0%) controls developed autoimmune encephalomyelitis in the first month of follow-up (HR >9999, P < 0.0001), but the risk between groups was not significantly different thereafter. Contrary to previous studies, our findings showed that dengue was associated with an increased short-term risk of a rare complication, autoimmune encephalomyelitis, but not associated with other autoimmune diseases.
Date:	2023-03-07
Relation:	PLoS Neglected Tropical Diseases. 2023 Mar 7;17(3):Article number e0011127.
Link to:	http://dx.doi.org/10.1371/journal.pntd.0011127
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1935-2735&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000945317600001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85149493384
Appears in Collections:	[Chia-Yu Chi] Periodical Articles [Others] Periodical Articles

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