國家衛生研究院 NHRI:Item 3990099045/14964
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    题名: Ecdysone signaling determines lateral polarity and remodels neurites to form Drosophila's left-right brain asymmetry
    作者: Sakamura, S;Hsu, FY;Tsujita, A;Abubaker, MB;Chiang, AS;Matsuno, K
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Left-right (LR) asymmetry of the brain is fundamental to its higher-order functions. The Drosophila brain's asymmetrical body (AB) consists of a structural pair arborized from AB neurons and is larger on the right side than the left. We find that the AB initially forms LR symmetrically and then develops LR asymmetrically by neurite remodeling that is specific to the left AB and is dynamin dependent. Additionally, neuronal ecdysone signaling inhibition randomizes AB laterality, suggesting that ecdysone signaling determines AB's LR polarity. Given that AB's LR asymmetry relates to memory formation, our research establishes AB as a valuable model for studying LR asymmetry and higher-order brain function relationships.
    日期: 2023-04-25
    關聯: Cell Reports. 2023 Apr 25;42(4):Article number 112337.
    Link to: http://dx.doi.org/10.1016/j.celrep.2023.112337
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2211-1247&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000989074000001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85153040143
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