國家衛生研究院 NHRI:Item 3990099045/14981
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    题名: Alkaloids and polyacetylenes from hippobroma iongiflora with antiangiogenesis properties
    作者: Ke, TY;Wang, SW;Chen, SR;Huang, DM;Lin, YS;Hwang, TL;Sun, WC;Cheng, YB
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Four new alkaloids, hippobrines A-D (1-4), along with three new polyacetylenes, hippobrenes A-C (5-7), were isolated from Hippobroma longiflora. Compounds 1-3 possess an unprecedented carbon skeleton. All of the new structures were determined by analyzing their mass and NMR spectroscopic data. The absolute configurations of 1 and 2 were confirmed by single-crystal X-ray analyses, and the absolute configurations of 3 and 7 were deduced using their ECD spectra. Plausible biogenetic pathways of 1 and 4 were proposed. In regard to bioactivities, all compounds (1-7) exhibited weak antiangiogenic activity against human endothelial progenitor cells, with IC50 values ranging from 21.1 ± 1.1 to 44.0 ± 2.3 μg/mL.
    日期: 2023-04-06
    關聯: Journal of Natural Products. 2023 Apr 6;86(4):719-729.
    Link to: http://dx.doi.org/10.1021/acs.jnatprod.2c00853
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0163-3864&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85152118719
    显示于类别:[黃東明] 期刊論文

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