國家衛生研究院 NHRI:Item 3990099045/14987
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    題名: Dietary inflammatory patterns are associated with serum TGs and insulin in adults: A community-based study in Taiwan
    作者: Chuang, SC;Wu, IC;Hsiung, CA;Chan, HT;Cheng, CW;Chen, HL;Chiu, YF;Lee, MM;Chang, HY;Hsu, CC
    貢獻者: Institute of Population Health Sciences;National Center for Geriatrics and Welfare Research
    摘要: BACKGROUND: Dietary patterns related to inflammation have become a focus of disease prevention but the patterns may vary among populations. OBJECTIVE: The study was conducted to determine Taiwanese dietary inflammatory patterns and evaluate their associations with biomarkers of lipid and glucose METHODS: Data were taken from 5,664 community-dwelling individuals aged ≥55 years old recruited in 2009 - 2013 in the Healthy Aging Longitudinal Study in Taiwan (HALST). Dietary data were obtained from a food frequency questionnaire. An empirical dietary inflammatory pattern (EDIP) was derived from reduced rank regression models that explained the serum hsCRP, plasma IL-6, and TNFR1. Cross-sectional associations between dietary scores and biomarkers of total cholesterol (TC); high-density lipoprotein cholesterol (HDLC); low-density lipoprotein cholesterol, triglyceride (TG); and ratios of TG/HDLC, TG/TC, fasting glucose, insulin, and HbA1c were analyzed via multiple linear regression and adjusted for major confounders. The false discovery rate (FDR)-adjusted p <0.05 was considered statistically significant. Abdominal obesity was defined as a waist circumference of ≥90 cm for men and ≥80 cm for women. RESULTS: Higher EDIP-HALST scores were associated with higher TG (per score increment: 1.62%, 95% CI: 0.58-2.76%; p(FDR)=0.01), TG/HDLC (2.01%, 0.67-3.37%; p(FDR)=0.01), and TG/TC (1.42%, 0.41-2.43%; p(FDR)=0.01) and nonlinearly associated with insulin, with those in the middle tertile had the highest serum insulin concentrations (means: 5.12 μIU/mL, 4.78-5.78; p(FDR) =0.04) in men, but not in women. No heterogeneity was detected between sexes. The associations with TG (1.23%, 0.19-2.23%; p(trend)=0.02), TG/HDLC (1.62%, 0.30-2.96%; p(trend)=0.02), and TG/TC (1.11%, 0.11-2.13%; p(trend)=0.03) were stronger in participants with abdominal obesity, but were borderline associated in participants with normal abdominal circumferences (all p(trend)=0.05). CONCLUSIONS: Inflammatory diets, as measured via EDIP-HALST, were associated with serum TG concentration, particularly in participants with abdominal obesity. These findings may suggest that developing disease prevention strategies using dietary inflammatory patterns may be different by populations.
    日期: 2023-06
    關聯: Journal of Nutrition. 2023 Jun;153(6):1783-1792.
    Link to: http://dx.doi.org/10.1016/j.tjnut.2023.04.015
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-3166&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001013557100001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85158110626
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