國家衛生研究院 NHRI:Item 3990099045/14996
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/14996


    Title: Case report: Heterogenous SMARCA4-deficient thoracic non-small cell lung carcinoma with various responses to nivolumab
    Authors: Lin, YT;Li, CF;Wu, HC;Jan, YH;Kuo, YH
    Contributors: National Institute of Cancer Research
    Abstract: SMARCA4-deficient non-small cell carcinoma is an aggressive neoplasm with poor outcome. Several studies have highlighted its immunochemistry, pathophysiology, and underlying mechanisms, but studies of its definite treatment are few. Here, we report on a 69-year-old male with heterogenous pathological presentations of SMARCA4-deficient non-small cell carcinoma. He initially presented with neck lymphadenopathies. Immunohistochemistry staining and genomic profiling confirmed the diagnosis of SMARCA4-deficient non-small cell carcinoma. The patient responded well to immune checkpoint inhibitors with nivolumab. However, new lesions with various pathological presentations and various responses to nivolumab appeared during the treatment course. The patient survived more than 3 years from the initial diagnosis. This case shows the efficacy of nivolumab to treat SMARCA4-deficient non-small cell lung carcinoma.
    Date: 2023-03-27
    Relation: Frontiers in Immunology. 2023 Mar 27;14:Article number 1131448.
    Link to: http://dx.doi.org/10.3389/fimmu.2023.1131448
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1664-3224&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000966200900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85152327936
    Appears in Collections:[Others] Periodical Articles

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