國家衛生研究院 NHRI:Item 3990099045/15029
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 914309      線上人數 : 1352
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/15029


    題名: Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population
    作者: Shi, J;Shiraishi, K;Choi, J;Matsuo, K;Chen, TY;Dai, J;Hung, RJ;Chen, K;Shu, XO;Kim, YT;Landi, MT;Lin, D;Zheng, W;Yin, Z;Zhou, B;Song, B;Wang, J;Seow, WJ;Song, L;Chang, IS;Hu, W;Chien, LH;Cai, Q;Hong, YC;Kim, HN;Wu, YL;Wong, MP;Richardson, BD;Funderburk, KM;Li, S;Zhang, T;Breeze, C;Wang, Z;Blechter, B;Bassig, BA;Kim, JH;Albanes, D;Wong, JYY;Shin, MH;Chung, LP;Yang, Y;An, SJ;Zheng, H;Yatabe, Y;Zhang, XC;Kim, YC;Caporaso, NE;Chang, J;Ho, JCM;Kubo, M;Daigo, Y;Song, M;Momozawa, Y;Kamatani, Y;Kobayashi, M;Okubo, K;Honda, T;Hosgood, DH;Kunitoh, H;Patel, H;Watanabe, SI;Miyagi, Y;Nakayama, H;Matsumoto, S;Horinouchi, H;Tsuboi, M;Hamamoto, R;Goto, K;Ohe, Y;Takahashi, A;Goto, A;Minamiya, Y;Hara, M;Nishida, Y;Takeuchi, K;Wakai, K;Matsuda, K;Murakami, Y;Shimizu, K;Suzuki, H;Saito, M;Ohtaki, Y;Tanaka, K;Wu, T;Wei, F;Dai, H;Machiela, MJ;Su, J;Kim, YH;Oh, IJ;Lee, VHF;Chang, GC;Tsai, YH;Chen, KY;Huang, MS;Su, WC;Chen, YM;Seow, A;Park, JY;Kweon, SS;et al.
    貢獻者: Institute of Population Health Sciences;National Institute of Cancer Research
    摘要: Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 controls; 54.5% never-smokers) and identified 12 novel susceptibility variants, bringing the total number to 28 at 25 independent loci. Transcriptome-wide association analyses together with colocalization studies using a Taiwanese lung expression quantitative trait loci dataset (n = 115) identified novel candidate genes, including FADS1 at 11q12 and ELF5 at 11p13. In a multi-ancestry meta-analysis of East Asian and European studies, four loci were identified at 2p11, 4q32, 16q23, and 18q12. At the same time, most of our findings in East Asian populations showed no evidence of association in European populations. In our studies drawn from East Asian populations, a polygenic risk score based on the 25 loci had a stronger association in never-smokers vs. individuals with a history of smoking (P(interaction) = 0.0058). These findings provide new insights into the etiology of lung adenocarcinoma in individuals from East Asian populations, which could be important in developing translational applications.
    日期: 2023-05-26
    關聯: Nature Communications. 2023 May 26;14:Article number 3043.
    Link to: http://dx.doi.org/10.1038/s41467-023-38196-z
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2041-1723&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001008971800001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85160220141
    顯示於類別:[熊昭] 期刊論文
    [蕭金福] 期刊論文
    [江士昇] 期刊論文
    [張憶壽] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB37236969.pdf3065KbAdobe PDF239檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋