國家衛生研究院 NHRI:Item 3990099045/15054
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    题名: Species distribution and antifungal susceptibility of clinical Aspergillus isolates: A multicentre study in Taiwan, 2016-2020
    作者: Wang, HC;Hsieh, MI;Choi, PC;Wu, WL;Wu, CJ;Hospitals, on behalf of the TSARM
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Background: Epidemiological knowledge is important to guide antifungal therapy. Objective: This multicentre study aimed to investigate the species distribution and antifungal susceptibility of Aspergillus isolates in Taiwan. Method: Four hundred and ninety--two clinical Aspergillus isolates, collected during 2016--2020, were identified by calmodulin sequencing and tested for antifungal susceptibility using CLSI M38--A3. The Cyp51A sequences of azole--resistant Aspergillus fumigatus and Aspergillus flavus isolates were analysed. Results: This collection comprised 30 species from eight Aspergillus sections--Flavi (33.5%), Nigri (26.0%), Fumigati (24.2%), Terrei (10.0%), Nidulantes (5.1%), Circumdati (0.8%), Restricti (0.2%) and Aspergillus (0.2%). Sections Fumigati, Flavi and Terrei were primarily represented by A. fumigatus (99.2%), A. flavus (95.8%) and A. terreus (100%), respectively. Section Nigri comprised nine species, mostly A. welwitschiae (60.2%), A. niger (12.5%), A. brunneoviolaceus (10.9%) and A. tubingensis (10.2%). A. fumigatus (39.6%) and A. flavus ( 26.4%) p redominated a mong 5 3 i solates f rom l ower r espiratory samples, whereas section Nigri species (46.2%) and A. terreus (29.2%) predominated among 65 isolates from ear samples. Reduced susceptibility to amphotericin B (minimal inhibitory concentration (MIC) > 1 mu g/mL) was noted in A. flavus (7.0%), A. terreus (6.1%), A. nidulans and section Circumdati ( A. flocculosus, A. subramanianii and A. westerdijkiae) isolates. Acquired azole resistance was observed in seven A. fumigatus (5.9%), all of which carried TR34/L98H or TR34/L98H/S297T/F495I mutation, and three A. flavus (1.9%), one of which carried G441S mutation. Reduced susceptibility to itraconazole (MIC > 1 mu g/mL) was noted in 55.5% of section Nigri isolates, mainly in A. welwitschiae, A. niger and A. tubingensis, whereas A. brunneoviolaceus, A. aculeatinus and A. japonicus were hypersusceptible to azoles. Anidulafungin was active against all isolates except for one isolate. Conclusions: This study depicted the molecular epidemiology and species--specific characteristics of Aspergillus in Taiwan, which aids in appropriate antifungal therapy and underlines the need of speciation and susceptibility testing of disease- -causing Aspergillus.
    日期: 2023-08
    關聯: Mycoses. 2023 Aug;66(8):711-722.
    Link to: http://dx.doi.org/10.1111/myc.13593
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0933-7407&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000979747700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85158026288
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