國家衛生研究院 NHRI:Item 3990099045/1506
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    题名: A novel strategy to increase heating efficiency in a split-focus ultrasound phased array
    作者: Liu, HL;Shih, TC;Chen, WS;Ju, KC
    贡献者: Division of Medical Engineering Research
    摘要: Focus splitting using sector-based phased arrays increases the necrosed volume in a single sonication and reduces the total treatment time in the treatment of large tumors. However, split-focus sonication results in a lower energy density and worse focal-beam distortion, which limits its usefulness in practical treatments. Here, we propose a new heating strategy involving consecutive strongly focused and split-focus sonications to improve the heating efficiency. Theoretical predictions including linear and thermal-dose-dependent attenuation change were employed to investigate potential factors of this strategy, and ex vivo tissue experiments were conducted to confirm its effectiveness. Results showed that the thermal lesions produced by the proposed strategy could be increased when comparing with the previous reported strategies. The proposed heating strategy also induces a thermal lesion more rapidly, and exhibits higher robustness to various blood perfusion conditions, higher robustness to various power/heating time combinations, and superiority to generate deep-seated lesions through tissues with complex interfaces. Possible mechanisms include the optimization of the thermal conduction created by the strongly focused sonication and the temperature buildup gained from thermally induced tissue attenuation change based on the theoretical analysis. This may represent a useful technique for increasing the applicability of split-focus and multiple-focus sonication techniques, and solve the obstacles encountered when attempting to use these methods to shorten the total clinical treatment time. (C) 2007 American Association of Physicists in Medicine.
    关键词: Radiology, Nuclear Medicine & Medical Imaging
    日期: 2007-07
    關聯: Medical Physics. 2007 Jul;34(7):2957-2967.
    Link to: http://dx.doi.org/10.1118/1.2746508
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0094-2405&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000248154700031
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34347405113
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