國家衛生研究院 NHRI:Item 3990099045/15089
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12189/12972 (94%)
造訪人次 : 955467      線上人數 : 730
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/15089


    題名: Extremely low dose of erythropoiesis-stimulating agent may be associated with increased mortality in hemodialysis patients
    作者: Yang, CW;Lin, MC;Shu, KH;Tung, KT;Tsai, WC;Yang, JY;Pai, MF;Wu, HY;Chiu, YL;Peng, YS;Hsu, SP;Wang, SH;Pan, SY
    貢獻者: National Center for Geriatrics and Welfare Research
    摘要: Introduction: Although high-dose erythropoiesis-stimulating agent (ESA) has been shown to increase mortality risk and adverse cardiovascular events in hemodialysis patients, the safety of extremely low-dose ESA is unclear. Methods: We retrospectively analyzed the association between ESA dose and mortality in the monthly dosing range of 0-43,000 U of equivalent epoetin alfa in 304 Taiwan hemodialysis patients by using Cox proportional hazard model and cubic spline model. Results: Compared with mean monthly ESA dose of 15,000-25,000 U (mean +/- standard deviation 20,609 +/- 2,662 U), monthly ESA dose of less than 15,000 U (mean +/- standard deviation 7,413 +/- 4,510 U) is associated with increased mortality. Monthly ESA dose of 25,001-43,000 U (mean +/- standard deviation 31,160 +/- 4,304 U) is not associated with higher mortality risk than monthly ESA dose of 15,000-25,000 U. The results were consistent in Cox proportional hazard models and cubic spline models. Subgroup analyses showed no significant heterogeneities among prespecified subgroups. Conclusions: Extremely low dose of ESA in hemodialysis patients may be associated with increased mortality risk. Future studies are warranted to prove this association.
    日期: 2023-05-23
    關聯: American Journal of Nephrology. 2023 May 23;54(1-2):25-34.
    Link to: http://dx.doi.org/10.1159/000529806
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0250-8095&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001007914100003
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85160874245
    顯示於類別:[王世亨] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI001007914100003.pdf359KbAdobe PDF90檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋