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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/15127
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| Title: | A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response |
| Authors: | Luo, Y;Kanai, M;Choi, W;Li, X;Sakaue, S;Yamamoto, K;Ogawa, K;Gutierrez-Arcelus, M;Gregersen, PK;Stuart, PE;Elder, JT;Forer, L;Schönherr, S;Fuchsberger, C;Smith, AV;Fellay, J;Carrington, M;Haas, DW;Guo, X;Palmer, ND;Chen, YDI;Rotter, JI;Taylor, KD;Rich, SS;Correa, A;Wilson, JG;Kathiresan, S;Cho, MH;Metspalu, A;Esko, T;Okada, Y;Han, B;Abe, N;Abecasis, G;Aguet, F;Albert, C;Almasy, L;Alonso, A;Ament, S;Anderson, P;Anugu, P;Applebaum-Bowden, D;Ardlie, K;Dan, A;Arnett, DK;Ashley-Koch, A;Aslibekyan, S;Assimes, T;Auer, P;Avramopoulos, D;Ayas, N;Balasubramanian, A;Barnard, J;Barnes, K;Barr, RG;Barron-Casella, E;Barwick, L;Beaty, T;Beck, G;Becker, D;Becker, L;Beer, R;Beitelshees, A;Benjamin, E;Benos, T;Bezerra, M;Bielak, L;Bis, J;Blackwell, T;Blangero, J;Boerwinkle, E;Bowden, DW;Bowler, R;Brody, J;Broeckel, U;Broome, J;Brown, D;Bunting, K;Burchard, E;Bustamante, C;Buth, E;Cade, B;Cardwell, J;Carey, V;Carrier, J;Carty, C;Casaburi, R;Romero, JPC;Casella, J;Castaldi, P;Chaffin, M;Chang, C;Chang, YC;Chasman, D;Chavan, S;Chen, BJ;Chen, WM;Choi, SH;Chuang, LM;Chung, M, .;et al. |
| Contributors: | Institute of Population Health Sciences |
| Abstract: | Fine-mapping to plausible causal variation may be more effective in multi-ancestry cohorts, particularly in the MHC, which has population-specific structure. To enable such studies, we constructed a large (n = 21,546) HLA reference panel spanning five global populations based on whole-genome sequences. Despite population-specific long-range haplotypes, we demonstrated accurate imputation at G-group resolution (94.2%, 93.7%, 97.8% and 93.7% in admixed African (AA), East Asian (EAS), European (EUR) and Latino (LAT) populations). Applying HLA imputation to genome-wide association study data for HIV-1 viral load in three populations (EUR, AA and LAT), we obviated effects of previously reported associations from population-specific HIV studies and discovered a novel association at position 156 in HLA-B. We pinpointed the MHC association to three amino acid positions (97, 67 and 156) marking three consecutive pockets (C, B and D) within the HLA-B peptide-binding groove, explaining 12.9% of trait variance. |
| Date: | 2021-10-05 |
| Relation: | Nature Genetics. 2021 Oct 05;53(10):1504-1516. |
| Link to: | http://dx.doi.org/10.1038/s41588-021-00935-7 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1061-4036&DestApp=IC2JCR |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85116750590 |
| Appears in Collections: | [鍾仁華] 期刊論文
[熊昭] 期刊論文
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| SCP85116750590.pdf | | 7171Kb | Adobe PDF | 85 | View/Open |
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