The primary barriers preventing the use of silicone-based catheters in medicine, especially for long-term indwelling, are bacterial-related illnesses, blood clotting, inflammation, and cell and tissue adhesion. To address the challenges related to the use of silicone-based catheters, this study presents a novel approach for developing a facile coating composed of anionic and amphiphilic fucoidan (Fu) and phototherapeutic molybdenum disulfide (MoS2) nanomicelles (Fu-MoS2 NMs) through oxygen plasma irradiation. The coating was consecutively applied to medical-grade silicone-based catheters. In this study, stable polymeric coatings were successfully prepared on previously used silicone rubber substrates through the formation of intermolecular bonds between active functional groups in Fu-MoS2 NMs and the side chains of residues on activated silicone interfaces. This study systematically verified a strong relationship between the composition of Fu-MoS2 NMs and their ability to effectively combat bacterial infections, inflammation, blood coagulation, and cell and tissue adhesion, simultaneously maintaining the biocompatibility of silicone rubber substrates. The findings of this study indicate that this simple yet effective interface design procedure can be readily employed for the development of silicone-based urinary catheters. The proposed strategy can be used for the development of diverse interface functionalization techniques for silicone-based medical devices, thus expanding the range of their medical applications.
Date:
2023-07-15
Relation:
Chemical Engineering Journal. 2023 Jul 15;468:Article number 143749.
