This Research Topic is very popular and important in cancer research, especially in the treatment of glioblastoma (GBM), a very aggressive malignant brain tumor. Despite efforts to understand mechanisms of treatment resistance in GBM, the high mortality associated with this disease remains a major challenge. One of the main factors contributing to this problem is resistance to chemotherapy, including the first-line chemotherapy drug temozolomide (TMZ) for GBM. One of the main ways cancer cells evade the effects of chemotherapy is through metabolic reprogramming, which involves changes in cellular metabolism to adapt to the cellular stress induced by chemotherapy. This reprogramming allows GBM cells to survive and continue to grow, leading to treatment resistance. Understanding the mechanisms of metabolic reprogramming and how it contributes to the development of resistance to GBM therapy is an active area of research and holds great promise for the development of new and more effective therapies for the disease.
Date:
2023-07-14
Relation:
Frontiers in Oncology. 2023 Jul 14;13:Article number 1220063.
