國家衛生研究院 NHRI:Item 3990099045/15264
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15264


    Title: A subset of cholinergic mushroom body neurons blocks long-term memory formation in Drosophila
    Authors: Chen, CC;Lin, HW;Feng, KL;Tseng, DW;de Belle, JS;Chiang, AS
    Contributors: Institute of Molecular and Genomic Medicine
    Abstract: Long-term memory (LTM) requires learning-induced synthesis of new proteins allocated to specific neurons and synapses in a neural circuit. Not all learned information, however, becomes permanent memory. How the brain gates relevant information into LTM remains unclear. In Drosophila adults, weak learning after a single training session in an olfactory aversive task typically does not induce protein-synthesis-dependent LTM. Instead, strong learning after multiple spaced training sessions is required. Here, we report that pre-synaptic active-zone protein synthesis and cholinergic signaling from the early α/β subset of mushroom body (MB) neurons produce a downstream inhibitory effect on LTM formation. When we eliminated inhibitory signaling from these neurons, weak learning was then sufficient to form LTM. This bidirectional circuit mechanism modulates the transition between distinct memory phase functions in different subpopulations of MB neurons in the olfactory memory circuit.
    Date: 2023-08-29
    Relation: Cell Reports. 2023 Aug 29;42(8):Article number 112974.
    Link to: http://dx.doi.org/10.1016/j.celrep.2023.112974
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2211-1247&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85167806565
    Appears in Collections:[Others] Periodical Articles

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