國家衛生研究院 NHRI:Item 3990099045/15281
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    题名: A hospital-based enterovirus 71 surveillance in southern vietnam, 2012-2020
    作者: Chang, Y;Khanh, TH;Chang, WC;Hung, NT;Luo, ST;Nhan, LNT;Chung, WY;Chien, YS;Lee, MS
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Intro: Enterovirus-A71 (EV-A71), a major cause of hand, foot, and mouth diseases (HFMD), has caused several outbreaks in Vietnam after its first identification in 2003. In 2011, a large-scale EV-A71 outbreak occurred in Southern Vietnam. To characterize epidemiological patterns of EV-A71 in Southern Vietnam, we conducted a hospital-based enterovirus surveillance in Children's Hospital No. 1 (CH1) Ho Chi Minh City over a 9-year period from 2012- 2020. Methods: Clinical samples (throat swabs and serum) were collected from CH1 inpatients with suspected enteroviruses infection for virus isolation in CH1. VP1- CODEHOP, a molecular assay, was performed for detection and genotyping of enteroviruses in National Health Research Institutes. Full genomes of selected EV-A71 viruses were also sequenced for phylogenetic analysis using Neighbor- joining method in MEGA 11 software. Findings: From 2012 to 2020, a total of 3184 HFMD inpatients were tested and 1693 of them (53%) were positive for enterovirus using VP1-CODEHOP, including 368 (11.56%) EV-A71 cases. Based on virus isolation conducted in 2012-2019, EV-A71 detection rate was 6.79% (177/2607). During the study period, EV-A71 was the top serotype detected in 2013, and 2016∼2018. Overall, the other prevalent serotypes were CV-A2, CV-A6, CV-A10 and CV-A16. Partial VP1 genes of 368 EV-A71 isolates were sequenced, 86.4% were genotype B5 and 13.6% C4. The predominant genotype was C4 in 2012 and shifted to B5 afterward. Based on full genome sequencing of five EV-A71 strains (3 B5 and 2 C4), the genotype C4 viruses were phylogenetically related to the C4 viruses isolated in China, genotype B5 were phylogenetically related to the B5 virus circulated in Malaysia, Singapore, and Taiwan. Conclusion:　EV-A71 outbreaks occurred every 2-3 years in Southern Vietnam and the predominant genotype circulating in Southern Vietnam was genotype B5. Development of EV-A71 vaccine is the priority and other prevalent serotypes should be included for developing multivalent vaccines in the future.
    日期: 2023-05
    關聯: International Journal of Infectious Diseases. 2023 May;130(Suppl.2 ):S102.
    Link to: http://dx.doi.org/10.1016/j.ijid.2023.04.255
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1201-9712&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001037898500244
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