國家衛生研究院 NHRI:Item 3990099045/15307
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    题名: Sustained release of nitric oxide-mediated angiogenesis and nerve repair by mussel-inspired adaptable microreservoirs for brain traumatic injury therapy
    作者: Liu, HC;Huang, CH;Chiang, MR;Hsu, RS;Chou, TC;Lu, TT;Lee, IC;Liao, LD;Chiou, SH;Lin, ZH;Hu, SH
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Traumatic brain injury (TBI) triggers inflammatory response and glial scarring, thus substantially hindering brain tissue repair. This process is exacerbated by the accumulation of activated immunocytes at the injury site, which contributes to scar formation and impedes tissue repair. In this study, a mussel-inspired nitric oxide-release microreservoir (MINOR) that combines the features of reactive oxygen species (ROS) scavengers and sustained NO release to promote angiogenesis and neurogenesis is developed for TBI therapy. The injectable MINOR fabricated using a microfluidic device exhibits excellent monodispersity and gel-like self-healing properties, thus allowing the maintenance of its structural integrity and functionality upon injection. Furthermore, polydopamine in the MINOR enhances cell adhesion, significantly reduces ROS levels, and suppresses inflammation. Moreover, a nitric oxide (NO) donor embedded into the MINOR enables the sustained release of NO, thus facilitating angiogenesis and mitigating inflammatory responses. By harnessing these synergistic effects, the biocompatible MINOR demonstrates remarkable efficacy in enhancing recovery in mice. These findings benefit future therapeutic interventions for patients with TBI.
    日期: 2023-09-15
    關聯: Advanced Healthcare Materials. 2023 Sep 15:Article number e2302315.
    Link to: http://dx.doi.org/10.1002/adhm.202302315
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2192-2640&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001070310700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85172376236
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