國家衛生研究院 NHRI:Item 3990099045/15374

NHRI > Center for Neuropsychiatric Research > Hwei-Hisen Chen > Conference Papers/Meeting Abstract > Item 3990099045/15374

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15374

Title:	Hericium erinaceus mycelium reduces the motivation to self-administer ketamine in male rats
Authors:	Chen, HH;Lee, MY
Contributors:	Center for Neuropsychiatric Research
Abstract:	Introduction: Ketamine therapy is considered a safe and effective way to alleviate symptoms associated with psychiatric disorders, including depression and anxiety [1]. However, recreational ketamine use has become popular in recent years [2]. The abuse liability of ketamine use has caused concern. The present study examined whether Hericium erinaceus (HE) mycelium and its major component erinacine A could reduce the motivation for ketamine Methods: Male Sprague-Dawley rats were trained to respond to intravenous ketamine (0.5 mg/kg/infusion) self-administration or food pellets. The effects of oral administration of HE mycelium or erinacine A on the motivation for ketamine and food were assessed using breakpoint test under a progressive ratio (PR) paradigm. Results: HE mycelium, but not erinacine A, significantly reduced the breakpoint for ketamine. In addition, HE mycelium did not affect the breakpoint for food reinforcement, while erinacine A significantly reduced the breakpoint for food reinforcement. Conclusions: The results reveal that HE mycelium is capable of attenuating the reinforcing efficacy of ketamine, which is not attributable to erinacine A. These findings suggest that a HE mycelium supplementation might reduce the risk to abuse ketamine in patients under ketamine therapy.
Date:	2023-07
Relation:	British Journal of Pharmacology. 2023 Jul;180(Suppl. 1):1034.
Link to:	https://doi.org/10.1111/bph.16112
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0007-1188&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:001043027400735
Appears in Collections:	[Hwei-Hisen Chen] Conference Papers/Meeting Abstract

Files in This Item:

File	Description	Size	Format
ISI001043027400735.pdf		180Kb	Adobe PDF	31	View/Open

Loading...