國家衛生研究院 NHRI:Item 3990099045/15417
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    题名: In situ forming of nitric oxide and electric stimulus for nerve therapy by wireless chargeable gold yarn-dynamos
    作者: Chiang, MR;Lin, YH;Zhao, WJ;Liu, HC;Hsu, RS;Chou, TC;Lu, TT;Lee, IC;Liao, LD;Chiou, SH;Chu, LA;Hu, SH
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Endogenous signals, namely nitric oxide (NO) and electrons, play a crucial role in regulating cell fate as well as the vascular and neuronal systems. Unfortunately, utilizing NO and electrical stimulation in clinical settings can be challenging due to NO's short half-life and the invasive electrodes required for electrical stimulation. Additionally, there is a lack of tools to spatiotemporally control gas release and electrical stimulation. To address these issues, an “electromagnetic messenger” approach that employs on-demand high-frequency magnetic field (HFMF) to trigger NO release and electrical stimulation for restoring brain function in cases of traumatic brain injury is introduced. The system comprises a NO donor (poly(S-nitrosoglutathione), pGSNO)-conjugated on a gold yarn-dynamos (GY) and embedded in an implantable silk in a microneedle. When subjected to HFMF, conductive GY induces eddy currents that stimulate the release of NO from pGSNO. This process significantly enhances neural stem cell (NSC) synapses' differentiation and growth. The combined strategy of using NO and electrical stimulation to inhibit inflammation, angiogenesis, and neuronal interrogation in traumatic brain injury is demonstrated in vivo.
    日期: 2023-11
    關聯: Advanced Science. 2023 Nov;10(33):Article number e2303566.
    Link to: http://dx.doi.org/10.1002/advs.202303566
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2198-3844&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001087492900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85174546390
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