國家衛生研究院 NHRI:Item 3990099045/15456

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Title:	Hepatocellular carcinoma with gastric metastasis mimicking a 4 cm gastrointestinal stromal tumor after a 3-year disease-free interval
Authors:	Chen, WT;Huang, SFK;Chang, ML;Liaw, YF
Contributors:	Institute of Molecular and Genomic Medicine
Abstract:	Hepatocellular carcinoma (HCC) is an aggressive tumor that usually occurs in patients with chronic liver disease and cir-rhosis. Surgical resection is an optimal treatment for HCC, but the 5-year recurrence rates are significantly high. The majority of recurrent HCCs occur through intrahepatic me-tastasis with local tumor progression, and less than 20% of recurrences are extrahepatic metastases. HCC with gastric metastasis is extremely rare, and it is easily misdiagnosed as primary gastric cancer with liver metastasis. An 80-year-old male chronic hepatitis B virus carrier had received lami-vudine and entecavir for years and was regularly followed up in the clinic. He had a 3.5 cm solitary HCC with micro-vascular invasion and received curative surgical resection in 2009. In 2013, he developed a 1.3 cm solitary HCC again and was treated with combination therapy with radiofre-quency ablation and pure ethanol injection. Afterwards, he was followed every 3-6 months and was HCC-free. Three years later, in 2016, endoscopy for intermittent epigastral-gia showed a solitary 4 cm intraluminal gastric subepithelial tumor without mucosal ulcers or erosions over the gastric fundus. All imaging studies, including computed tomogra-phy, favored the diagnosis of gastrointestinal stromal tumor (GIST), but the pathology of the tumor proved to be HCC. The patient did not receive any systemic anticancer therapy but only wedge resection of the stomach and remained tu- mor-and HCC-free until his latest clinic visit in 2023. The current case is unique and indicates the possibility of HCC with late solitary gastric metastasis mimicking GIST. Com-plete gastric tumor resection ensured an extremely good outcome for the patient, which is different from the devastating prognosis of most cases of HCC with gastric metas-tasis.
Date:	2024-02
Relation:	Journal of Clinical and Translational Hepatology. 2024 Feb:12(2):218-221.
Link to:	http://dx.doi.org/10.14218/JCTH.2023.00282
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2225-0719&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:001101054600001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85187182876
Appears in Collections:	[Shiu-Feng Kathy Huang] Periodical Articles

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