國家衛生研究院 NHRI:Item 3990099045/15457
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    題名: Air pollution associate with advanced hepatic fibrosis among patients with chronic liver disease
    作者: Jang, TY;Ho, CC;Liang, PC;Wu, CD;Wei, YJ;Tsai, PC;Hsu, PY;Hsieh, MY;Lin, YH;Hsieh, MH;Wang, CW;Yang, JF;Yeh, ML;Huang, CF;Chuang, WL;Huang, JF;Cheng, YY;Dai, CY;Chen, PC;Yu, ML
    貢獻者: NHRI Graduate Student Program;National Institute of Environmental Health Sciences
    摘要: We aimed to investigate the association between air pollution and advanced fibrosis among patients with metabolic associated fatty liver disease (MAFLD) and chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. A total of 1376 participants who were seropositive for HBV surface antigen (HBsAg) or antibodies to HCV (anti-HCV) or had abnormal liver function in a community screening program from 2019 to 2021 were enrolled for the assessment of liver fibrosis using transient elastography. Daily estimates of air pollutants (particulate matter <= 2.5 mu m in diameter [PM2.5], nitrogen dioxide [NO2], ozone [O-3] and benzene) were aggregated into mean estimates for the previous year based on the date of enrolment. Of the 1376 participants, 767 (52.8%) and 187 (13.6) had MAFLD and advanced fibrosis, respectively. A logistic regression analysis revealed that the factors associated with advanced liver fibrosis were HCV viremia (odds ratio [OR], 3.13; 95% confidence interval [CI], 2.05-4.77; p < 0.001), smoking (OR, 1.79; 95% CI, 1.16-2.74; p = 0.01), age (OR, 1.04; 95% CI, 1.02-1.05; p < 0.001) and PM2.5 (OR, 1.10; 95% CI, 1.05-1.16; p < 0.001). Linear regression analysis revealed that LSM was independently correlated with PM2.5 (beta: 0.134; 95% CI: 0.025, 0.243; p = 0.02). There was a dose-dependent relationship between different fibrotic stages and the PM2.5 level (the PM2.5 level in patients with fibrotic stages 0, 1-2 and 3-4: 27.9, 28.4, and 29.3 mu g/m(3), respectively; trend p < 0.001). Exposure to PM2.5, as well as HBV and HCV infections, is associated with advanced liver fibrosis in patients with MAFLD. There was a dose-dependent correlation between PM2.5 levels and the severity of hepatic fibrosis.
    日期: 2024-03
    關聯: Kaohsiung Journal of Medical Sciences. 2024 Mar;40(3):304-314.
    Link to: http://dx.doi.org/10.1002/kjm2.12781
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1607-551X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001103090700001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85176585011
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