國家衛生研究院 NHRI:Item 3990099045/15498
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    题名: Elizabethkingia anophelis outer membrane vesicles as a novel vaccine candidate against infection: Insights into immune response and potential for passive immunity
    作者: Yang, YS;Chen, HJ;Chen, XC;Tang, HJ;Chang, FJ;Huang, YL;Pan, YL;Kesavan, DK;Chen, HY;Shang, HS;Kuo, SC;Chen, TL;Chiang, MH
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Elizabethkingia anophelis, a Gram-negative pathogen, causes infections such as bacteraemia, pneumonia, and neonatal meningitis. The pathogen resists most antimicrobial classes, making novel approaches urgently needed. In natural settings, Gram-negative bacteria secrete outer membrane vesicles (OMVs) that carry important molecules in the bacterial life cycle. These OMVs are enriched with proteins involved in virulence, survival, and carbohydrate metabolism, making them a promising source for vaccine development against the pathogen. This study investigated the efficacy of imipenem-induced OMVs (iOMVs) as a vaccine candidate against E. anophelis infection in a mouse pneumonia model. Mice immunized with iOMVs were completely protected during lethal-dose challenges. Passive immunization with hyperimmune sera and splenocytes conferred protection against lethal pneumonia. Further investigation is needed to understand the mechanisms underlying the protective effects of iOMV-induced passive immunity, such as the action on specific antibody subclasses or T cell subsets.
    日期: 2023-11-28
    關聯: mSphere. 2023 Nov 28;Article number e0040023.
    Link to: http://dx.doi.org/10.1128/msphere.00400-23
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2379-5042&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001110218100001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85181262112
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