國家衛生研究院 NHRI:Item 3990099045/15529
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15529


    Title: Evaluating polygenic risk scores for predicting cardiometabolic traits and disease risks in the Taiwan Biobank
    Authors: Chung, RH;Chuang, SY;Zhuang, YS;Jhang, YS;Huang, TH;Li, GH;Chang, IS;Hsiung, CA;Chiou, HY
    Contributors: Institute of Population Health Sciences;National Institute of Cancer Research
    Abstract: Type 2 diabetes (T2D) and hypertension are common comorbidities and, along with hyperlipidemia, serve as risk factors for cardiovascular diseases. This study aimed to evaluate the predictive value of polygenic risk scores (PRSs) on cardiometabolic traits related to T2D, hypertension, and hyperlipidemia and the incidence of these three diseases in Taiwan Biobank samples. Using publicly available, large-scale genome-wide association studies summary statistics, we constructed cross-ethnic PRSs for T2D, hypertension, body mass index, and nine quantitative traits typically used to define the three diseases. A composite PRS (cPRS) for each of the nine traits was constructed by aggregating the significant PRSs of its genetically correlated traits. The associations of each of the nine traits at baseline as well as the change of trait values during a 3- to 6-year follow-up period with its cPRS were evaluated. The predictive performances of cPRSs in predicting future incidences of T2D, hypertension, and hyperlipidemia were assessed. The cPRSs had significant associations with baseline and changes of trait values in 3-6 years and explained a higher proportion of variance for all traits than individual PRSs. Furthermore, models incorporating disease-related cPRSs, along with clinical features and relevant trait measurements achieved area under the curve values of 87.8%, 83.7%, and 75.9% for predicting future T2D, hypertension, and hyperlipidemia in 3-6 years, respectively.
    Date: 2024-01-11
    Relation: HGG Advances. 2024 Jan 11;5(1):Article number 100260.
    Link to: http://dx.doi.org/10.1016/j.xhgg.2023.100260
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2666-2477&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85180792876
    Appears in Collections:[Ren-Hua Chung] Periodical Articles
    [Shu-Chun Chuang] Periodical Articles
    [Hung-Yi Chiou] Periodical Articles
    [Chao A. Hsiung] Periodical Articles
    [I-Shou Chang] Periodical Articles

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