 |
English
|
正體中文
|
简体中文
|
Items with full text/Total items : 12145/12927 (94%)
Visitors : 904107
Online Users : 857
|
|
|
Loading...
|
Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/15540
|
| Title: | Pathological granuloma fibrosis induced by agar-embedded Mycobacterium abscessus in C57BL/6JNarl mice |
| Authors: | Yang, SJ;Hsu, CH;Lai, CY;Tsai, PC;Song, YD;Yeh, CC;Chen, YY;Dou, HY |
| Contributors: | National Institute of Infectious Diseases and Vaccinology;Pathology Core Laboratory |
| Abstract: | INTRODUCTION: Pulmonary granuloma diseases caused by Mycobacterium abscessus (M. abscessus) have increased in past decades, and drug-resistance in this pathogen is a growing public health concern. Therefore, an animal model of chronic granuloma disease is urgently needed. METHODS: In this study, M. abscessus embedded within agar beads (agar-AB) was used to develop such a model in C57BL/6JNarl mice. RESULTS: Chronic infection was sustained for at least 3 months after agar-AB infection, visible granulomas spread in the lungs, and giant cells and foamy cells appeared in the granulomas. More importantly, pulmonary fibrosis progressed for 3 months, and collagen fibers were detected by Masson trichrome staining. Further, inducible nitric oxide synthase (iNOS) was highly expressed within the alveolar space, and the fibrosis-mediator transforming growth factor beta (TGF-β) began to be expressed at 1 month. Hypoxia-inducible factor (HIF-1α) expression also increased, which aided in normalizing oxygen partial pressure. DISCUSSION: Although the transient fibrosis persisted for only 3 months, and the pulmonary structure resolved when the pathogen was cleard, this pulmonary fibrosis model for M. abscessus infection will provide a novel test platform for development of new drugs, regimens, and therapies. |
| Date: | 2023-12-11 |
| Relation: | Frontiers in Immunology. 2023 Dec 11;14:Article number 1277745. |
| Link to: | http://dx.doi.org/10.3389/fimmu.2023.1277745 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1664-3224&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:001129885700001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85180704376 |
| Appears in Collections: | [杜鴻運] 期刊論文
[其他] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| PUB38146374.pdf | | 5883Kb | Adobe PDF | 168 | View/Open |
|
All items in NHRI are protected by copyright, with all rights reserved.
|
