國家衛生研究院 NHRI:Item 3990099045/15550

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Title:	Block copolymer-stabilized metal–organic framework hybrids loading Pd nanoparticles enable tumor remission through near-infrared photothermal therapy
Authors:	Li, SW;Hsieh, MF;Hong, T;Chen, P;Osada, K;Liu, X;Aoki, I;Yu, J;Wu, KCW;Cabral, H
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Metal–organic frameworks (MOFs), such as the magnetic resonance imaging-fit MIL-100 based on Fe, are gaining significant attention as versatile theranostics with high-loading capability. Moreover, as MOFs can be engineered to target tumors, there is much interest in applying them for precise pin-point treatment of cancer. Herein, Pd nanoparticles within MIL-100(Fe) are generated to create MOFs with remarkable photothermal conversion properties for cancer therapy. The Pd-loaded MIL-100(Fe) (Pd@MIL-100(Fe)) are stabilized with biocompatible block copolymers to generate MOFs with PEGylated surfaces. This is achieved by directly mixing poly(ethylene glycol)-poly(L-aspartic acid) (PEG-p(Asp)) or dopamine-modified PEG-p(Asp) (PEG-p(Asp-Dopa)) block copolymers with the MOFs in aqueous conditions. The resulting block copolymer-stabilized MOF hybrids are stable in physiological conditions. Particularly, the Pd@MIL-100(Fe)/PEG-p(Asp-Dopa) hybrids show enhanced blood circulation and increased accumulation in B16F10 melanoma. Furthermore, when irradiated with 808 nm light, the Pd@MIL-100(Fe)/PEG-p(Asp-Dopa) hybrids rapidly increase the temperature to 50 °C, enabling tumor remission. The surface-stabilized Pd@MIL-100(Fe)/polymer hybrids open viable opportunities for innovating MOF/polymer hybrid-based approaches for drug delivery.
Date:	2024-01
Relation:	Advanced NanoBiomed Research. 2024 Jan;4(1):Article nubmer 2300107.
Link to:	http://dx.doi.org/10.1002/anbr.202300107
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2699-9307&DestApp=IC2JCR
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85178238064
Appears in Collections:	[Chia-Wen Wu] Periodical Articles

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