國家衛生研究院 NHRI:Item 3990099045/15563

NHRI > National Center for Geriatrics and Welfare Research > Pei-Chun Chen > Periodical Articles > Item 3990099045/15563

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15563

Title:	Dose of selective serotonin reuptake inhibitors and risk of upper gastrointestinal bleeding in older adults
Authors:	Li, YH;Hang, LW;Muo, CH;Chen, SJ;Chen, PC
Contributors:	National Center for Geriatrics and Welfare Research
Abstract:	Background: Selective serotonin reuptake inhibitors (SSRIs) have been associated with an increased risk of upper gastrointestinal bleeding (UGIB) in older patients but little is known about the risk associated with individual SSRI drugs and doses. Aims: To quantify the risk of UGIB in relation to individual SSRI use in older adults. Methods: We conducted a nested case–control study within a cohort of 9565 patients aged ⩾65 years prescribed SSRIs from 2000 to 2013 using claims data of universal health insurance in Taiwan. Incident cases of UGIB during the follow-up period were identified and matched with three control subjects. Conditional logistic regression was used to estimate the odds ratio (OR) of UGIB associated with individual SSRI use and cumulative dose. Results: UGIB risk increased with the increasing cumulative doses of SSRIs (adjusted OR: 1.28, 95% confidence interval (CI): 1.02–1.62 for the highest vs. the lowest tertile). Compared with users of other SSRIs, fluoxetine users were at an increased risk of UGIB (adjusted OR: 1.25, 95% CI: 1.03–1.50) with a dose–response manner, whereas paroxetine users had 29% decreased odds (95% CI: 0.56–0.91). The increased risk was only observed among current fluoxetine users. Conclusions: Fluoxetine therapy was associated with an increased risk of UGIB in a dose–response manner among older adults.
Date:	2024-02
Relation:	Journal of Psychopharmacology. 2024 Feb;38(2):137-144.
Link to:	http://dx.doi.org/10.1177/02698811231218955
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0269-8811&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:001128496300001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85180234352
Appears in Collections:	[Pei-Chun Chen] Periodical Articles

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