國家衛生研究院 NHRI:Item 3990099045/15605
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15605


    Title: Efficacy of derinat as a treatment for murine and androgenetic alopecia (AGA) patients
    Authors: Wu, CY;Chen, WC;Hsieh, CH;Liang, YF;Li, WJ;Shen, H;Wei, WY;Chou, TY;Chiu, YC;Huang, H;Hsu, WL
    Contributors: National Center for Geriatrics and Welfare Research
    Abstract: Androgenetic alopecia (AGA), one of the most common types of hair loss, is associated with oxidative stress, inflammation and aging. Derinat, a transient receptor potential canonical channels (TRPCs) inhibitor, restrains TRPCs-mediated increase intracellular Ca2+ signaling, which initiates the skin aging process with intracellular reactive oxygen species (ROS) accumulation. This study investigated whether Derinat protected skin from oxidative stress-induced damage and aging, thus inhibiting AGA pathogenesis.
    Date: 2023-11-10
    Relation: Translational Medicine Communications. 2023 Nov 10;8:Article number 25.
    Link to: https://doi.org/10.1186/s41231-023-00159-3
    Appears in Collections:[Wen-Li Hsu] Periodical Articles

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