國家衛生研究院 NHRI:Item 3990099045/15609
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    題名: Air pollution as a potential a risk factor for hepatocellular carcinoma in Taiwanese patients after adjusting for chronic viral hepatitis
    作者: Jang, TY;Ho, CC;Wu, CD;Dai, CY;Chen, PC
    貢獻者: NHRI Graduate Student Program;National Institute of Environmental Health Sciences
    摘要: BACKGROUND: Air pollution is a risk factor for hepatocellular carcinoma (HCC). However, the effect of air pollution on HCC risk in patients with hepatitis remains unclear. METHODS: This cross-sectional study recruited 348 patients with chronic hepatitis who were tested for serum hepatitis B surface antigen (HBsAg) and for antibodies against hepatitis B core antigen (HBcIgG) and hepatitis C virus (anti-HCV) in 2022. The diagnosis of HCC was based on the International Classification of Diseases, 10 th revision (ICD-10). Daily estimates of air pollutants were aggregated into mean estimates for the previous year based on the date of recruitment or HCC diagnosis. RESULTS: Out of 348 patients, twelve had HCC (3.4%). Patients with HCC were older (71.7 years vs 50.9 year; p=0.004), had higher proportion of HBsAg seropositivity (41.7% vs 5.1%; p<0.001), and substantially higher levels of particulate matter 2.5 (PM2.5) (21.5 μg/m 3 vs 18.2 μg/m 3; p=0.05). Logistic regression analysis revealed that the factors associated with HCC were age (OR: 1.10; CI: 1.03-1.17; p=0.01), PM2.5 level (OR: 1.51; CI: 1.02-2.23; p=0.04), and HBsAg seropositivity (OR: 6.60; CI: 1.51-28.85; p=0.01). There was a combined effect of PM2.5 and HBsAg seropositivity on the risk of HCC development (OR: 22.17; CI: 3.33-147.45; p=0.001). CONCLUSION: In this study, we demonstrated that PM2.5 and HBsAg seropositivity were associated with HCC occurrence and had synergistic effects after adjusting for confounding factors.
    日期: 2024-03
    關聯: Journal of the Chinese Medical Association. 2024 Mar 1;87(3):287-291.
    Link to: http://dx.doi.org/10.1097/jcma.0000000000001053
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1726-4901&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001179373600014
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85186659930
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