國家衛生研究院 NHRI:Item 3990099045/15618
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    題名: Exploring the relationship between gut microbiome composition and blood indole-3-acetic acid in hemodialysis patients
    作者: Wu, PH;Tseng, YF;Liu, W;Chuang, YS;Tai, CJ;Tung, CW;Lai, KY;Kuo, MC;Chiu, YW;Hwang, SJ;Hung, WC;Lin, YT
    貢獻者: Institute of Biotechnology and Pharmaceutical Research
    摘要: Indole-3-acetic acid (IAA), a protein-bound uremic toxin resulting from gut microbiota-driven tryptophan metabolism, increases in hemodialysis (HD) patients. IAA may induce endothelial dysfunction, inflammation, and oxidative stress, elevating cardiovascular and cognitive risk in HD patients. However, research on the microbiome-IAA association is limited. This study aimed to explore the gut microbiome's relationship with plasma IAA levels in 72 chronic HD patients aged over 18 (August 2016-January 2017). IAA levels were measured using tandem mass spectrometry, and gut microbiome analysis utilized 16s rRNA next-generation sequencing. Linear discriminative analysis effect size and random forest analysis distinguished microbial species linked to IAA levels. Patients with higher IAA levels had reduced microbial diversity. Six microbial species significantly associated with IAA levels were identified; Bacteroides clarus, Bacteroides coprocola, Bacteroides massiliensi, and Alisteps shahii were enriched in low-IAA individuals, while Bacteroides thetaiotaomicron and Fusobacterium varium were enriched in high-IAA individuals. This study sheds light on specific gut microbiota species influencing IAA levels, enhancing our understanding of the intricate interactions between the gut microbiota and IAA metabolism.
    日期: 2024-01-10
    關聯: Biomedicines. 2024 Jan 10;12(1):Article number 148.
    Link to: http://dx.doi.org/10.3390/biomedicines12010148
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2227-9059&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001149142200001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85183368722
    顯示於類別:[童俊維] 期刊論文

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