國家衛生研究院 NHRI:Item 3990099045/15673
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    題名: Mesenchymal stromal/stem cells know best: The remarkable complexities of its interactions with polymorphonuclear neutrophils
    作者: Wang, LT;Lee, W;Liu, KJ;Sytwu, HK;Yen, ML;Yen, BL
    貢獻者: National Institute of Cancer Research;National Institute of Infectious Diseases and Vaccinology;Institute of Cellular and Systems Medicine
    摘要: Polymorphonuclear neutrophils (PMNs), the predominant immune cell type in humans, have long been known as first-line effector cell against bacterial infections mainly through phagocytosis and production of reactive oxygen species (ROS). However, recent research has unveiled novel and pivotal roles of these abundant but short-lived granulocytes in health and disease. Human mesenchymal stromal/stem cells (MSCs), renowned for their regenerative properties and modulation of T lymphocytes from effector to regulatory phenotypes, exhibit complex and context-dependent interactions with PMNs. Regardless of species or source, MSCs strongly abrogate PMN apoptosis, a critical determinant of PMN function, except if PMNs are highly stimulated. MSCs also have the capacity to fine-tune PMN activation, particularly in terms of CD11b expression and phagocytosis. Moreover, MSCs can modulate numerous other PMN functions, spanning migration, ROS production, and neutrophil extracellular trap (NET) formation/NETosis, but directionality is remarkably dependent on the underlying context: in normal non-diseased conditions, MSCs enhance PMN migration and ROS production, whereas in inflammatory conditions, MSCs reduce both these functions and NETosis. Furthermore, the state of the MSCs themselves, whether isolated from diseased or healthy donors, and the specific secreted products and molecules, can impact interactions with PMNs; while healthy MSCs prevent PMN infiltration and NETosis, MSCs isolated form cancer patients promote these functions. This comprehensive analysis highlights the intricate interplay between PMNs and MSCs and its profound relevance in healthy and pathological conditions, shedding light on how to best strategize use of MSCs in the expanding list of diseases with PMN involvement.
    日期: 2024-05
    關聯: Stem Cells. 2024 May 15;42(5):403-415.
    Link to: http://dx.doi.org/10.1093/stmcls/sxae011
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1066-5099&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001176172600001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85193309109
    顯示於類別:[劉柯俊] 期刊論文
    [司徒惠康] 期刊論文
    [顏伶汝] 期刊論文

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