國家衛生研究院 NHRI:Item 3990099045/15674
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    題名: Asymmetric neurons are necessary for olfactory learning in the Drosophila brain
    作者: Abubaker, MB;Hsu, FY;Feng, KL;Chu, LA;de Belle, JS;Chiang, AS
    貢獻者: Institute of Molecular and Genomic Medicine
    摘要: Animals have complementary parallel memory systems that process signals from various sensory modalities. In the brain of the fruit fly Drosophila melanogaster, mushroom body (MB) circuitry is the primary associative neuropil, critical for all stages of olfactory memory. Here, our findings suggest that active signaling from specific asymmetric body (AB) neurons is also crucial for this process. These AB neurons respond to odors and electric shock separately and exhibit timing-sensitive neuronal activity in response to paired stimulation while leaving a decreased memory trace during retrieval. Our experiments also show that rutabaga-encoded adenylate cyclase, which mediates coincidence detection, is required for learning and short-term memory in both AB and MB. We observed additive effects when manipulating rutabaga co-expression in both structures. Together, these results implicate the AB in playing a critical role in associative olfactory learning and short-term memory.
    日期: 2024-03-11
    關聯: Current Biology. 2024 Mar 11;34(5):946-957.e4.
    Link to: http://dx.doi.org/10.1016/j.cub.2024.01.037
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0960-9822&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85186084985
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