國家衛生研究院 NHRI:Item 3990099045/15678

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Title:	Impact of the trans-ancestry polygenic risk score on type 2 diabetes risk, onset age and progression among population in Taiwan
Authors:	Wang, SH;Huang, YC;Cheng, CW;Chang, YW;Liao, WL
Contributors:	National Center for Geriatrics and Welfare Research
Abstract:	T2D prevalence in adults at a younger age has increased but the disease status may go unnoticed. This study aimed to determine whether the onset age and subsequent diabetic complications can be attributed to the polygenic architecture of T2D in the Taiwan Han population. A total of 9,627 cases with T2D and 85,606 controls from the Taiwan Biobank were enrolled. Three diabetic polygenic risk scores (PRSs)-PRS_EAS and PRS_EUR, and a trans-ancestry PRS (PRS_META)-calculated using summary statistic from East Asian and European populations. The onset age was identified by linking to the National Taiwan Insurance Research Database and the incidence of different diabetic complications during follow-up was recorded. PRS_META (7.4%) explained a higher variation for T2D status. And the higher percentile of PRS is also correlated with higher percentage of T2D family history and prediabetes status. More, the PRS was negatively associated with onset age (beta = -0.91 years), and this was more evident among males (beta = -1.11 vs. -0.76 for males and females, respectively).The hazard ratio of diabetic retinopathy (DR) and diabetic foot were significantly associated with PRS_EAS and PRS_META, respectively. However, the PRS was not associated with other diabetic complications, including diabetic nephropathy, cardiovascular disease, and hypertension. Our findings indicated that diabetic PRS which combined susceptibility variants from cross-population could be used as a tool for early screening of T2D, especially for high-risk populations, such as individuals with high genetic risk, and may be associated with the risk of complications in T2D subjects.
Date:	2024-05
Relation:	American Journal of Physiology-Endocrinology and Metabolism. 2024 May;326(5):E547-E554.
Link to:	http://dx.doi.org/10.1152/ajpendo.00252.2023
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0193-1849&DestApp=IC2JCR
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85190902564
Appears in Collections:	[Shi-Heng Wang] Periodical Articles

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