國家衛生研究院 NHRI:Item 3990099045/15680
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15680


    Title: Degeneration of the olfactory system in a murid rodent that evolved diurnalism
    Authors: Liao, BY;Weng, MP;Chang, TY;Chang, AY;Ching, YH;Wu, CH
    Contributors: Institute of Population Health Sciences;Laboratory Animal Center
    Abstract: In mammalian research, it has been debated what can initiate an evolutionary trade-off between different senses, and the phenomenon of sensory trade-off in rodents, the most abundant mammalian clade, is not evident. The Nile rat (Arvicanthis niloticus), a murid rodent, recently adapted to a diurnal niche through an evolutionary acquisition of daylight vision with enhanced visual acuity. As such, this model provides an opportunity for a cross-species investigation where comparative morphological and multi-omic analyses of the Nile rat are made with its closely related nocturnal species, e.g., the mouse (Mus musculus) and the rat (Rattus norvegicus). Thus, morphological examinations were performed, and evolutionary reductions in relative sizes of turbinal bone surfaces, the cribriform plate, and the olfactory bulb were discovered in Nile rats. Subsequently, we compared multiple murid genomes, and profiled olfactory epithelium transcriptomes of mice and Nile rats at various ages with RNA sequencing (RNA-seq). The results further demonstrate that, in comparison with mouse olfactory receptor (OR) genes, Nile rat OR genes have experienced less frequent gain, more frequent loss, and more frequent expression reduction during their evolution. Furthermore, functional degeneration of coding sequences in the Nile rat lineage was found in OR genes, yet not in other genes. Taken together, these results suggest that acquisition of improved vision in the Nile rat has been accompanied by degeneration of both olfaction-related anatomical structures and OR gene repertoires, consistent with the hypothesis of an olfaction-vision tradeoff initiated by the switch from a nocturnal to a diurnal lifestyle in mammals.
    Date: 2024-02-20
    Relation: Molecular Biology and Evolution. 2024 Feb 20;41(3):Article number msae037.
    Link to: http://dx.doi.org/10.1093/molbev/msae037
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0737-4038&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001191312300010
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85189167485
    Appears in Collections:[Ben-Yang Liao] Periodical Articles
    [Others] Periodical Articles

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