國家衛生研究院 NHRI:Item 3990099045/15703
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15703


    Title: Age at onset of type 1 diabetes between puberty and 30 years old is associated with increased diabetic nephropathy risk
    Authors: Lin, YB;Chang, TJ;Sheu, WHH;Lo, SH;Yeh, YP;Huang, CN;Hwu, CM;Hsieh, CH;Ou, HY;Chuang, LM;Chen, JF;Chen, YC;Peng, YH;Chen, ST;Hsu, SR;Hsieh, YL;Chu, CH;Lu, CH;Lee, YJ;Chen, HF;Chen, CC;Lee, CC;Hsiao, PJ;Tsai, ST;Chen, S;Su, CC;Lin, YL;Bau, CT;Liao, CC;Kuo, TY;Chen, HJ;Wang, CC;Cheng, CJ;Lin, YL;Chen, SC;Chen, CY;Huang, HY;Chen, JR;Lo, HJ;Yu, NC;Liu, WC;Wu, CH;Chen, DW;Shen, DC;Chung, WC
    Contributors: Institute of Molecular and Genomic Medicine
    Abstract: Diabetic nephropathy is a critical complication of patients with type 1 diabetes, while epidemiological studies were scarce among Asian countries. We conducted a cross-sectional study to identify factors associated with diabetic nephropathy by questionnaires, using student’s t-test, chi-square test, and multivariable logistic regression. Among 898 participants, 16.7% had diabetic nephropathy. Compared with non-diabetic nephropathy patients, the patients with diabetic nephropathy had significantly higher percentage with onset age of type 1 diabetes between puberty and under 30 years old (female ≥ 12 or male ≥ 13 years old to 29 years old), longer diabetes duration, having family history of diabetes and diabetic nephropathy, accompanied with hypertension, hyperlipidemia, or coronary artery disease (CAD). Compared with patients with onset age before puberty, the odds of diabetic nephropathy occurrence increased to 1.61 times in patients with onset age between puberty and under 30 years old (p = 0.012) after adjusting diabetes duration. Age of diabetes onset between puberty and under 30 years old, diabetes duration, HbA1c, hospital admission within 3 years, diabetic retinopathy, hypertension, systolic blood pressure (SBP), triglyceride levels, and use of angiotensin converting enzyme inhibitor (ACEI) and/or angiotensin receptor blockers (ARB) were independent factors associated with diabetic nephropathy Screening for proteinuria is important in daily clinical practice and should be part of diabetes self-management education for patients with type 1 diabetes.
    Date: 2024-02-13
    Relation: Scientific Reports. 2024 Feb 13;14:Article number 3611.
    Link to: http://dx.doi.org/10.1038/s41598-024-54137-2
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85185095717
    Appears in Collections:[Huey-Herng Sheu] Periodical Articles

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