國家衛生研究院 NHRI:Item 3990099045/15710
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    题名: A biomimetic micropillar wound dressing with flavone and polyphenol control release in vitro and in vivo
    作者: Cheng, TH;Lin, RH;Cheng, YS;Shih, PK;Show, PL;Chen, HY;Nakmee, PS;Chang, JJ;Huang, DM;Wang, HMD
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Background: Wound healing is a complex and dynamic process involving the replacement of devitalized and missing cellular structures and tissue layers. Methods: This study involved developing a drug-loaded biomimetic micropillar wound dressing based upon inspiration from witnessing the adhesive ability in a gecko's footpad. The conformal adhesion was set up by applying a soft elastomer thin film on the developed wound dressing surfaces. The results showed that the developed surfaces prepared based on polydimethylsiloxane (PDMS) had low surface free energy, high chemical stability, and good plasticity. Astaxanthin (AST) and curcumin were applied as the patch's bioactive compounds to help accelerate the wound healing process. Results: The results showed that the developed surfaces prepared based on polydimethylsiloxane (PDMS) had low surface free energy, high chemical stability, and good plasticity. Astaxanthin (AST) and curcumin were applied as the patch's bioactive compounds to help accelerate the wound healing process. The results indicate that the developed biomimetic micropillar patches could release the loaded drugs and significantly increase cell viability and collagen content to 20 % ∼ 25 % in vitro and in vivo. Conclusion: In summation, the primary purpose of this study has been to design a novel encapsulated carrier (micropillar patch) for use in adjustable drug release, while combining with the biomimetic microstructure to reach wound healing through percutaneous absorption.
    日期: 2024-07
    關聯: Journal of the Taiwan Institute of Chemical Engineers. 2024 Jul;160:Article number 105385.
    Link to: http://dx.doi.org/10.1016/j.jtice.2024.105385
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1876-1070&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001257720800001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85185606734
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