國家衛生研究院 NHRI:Item 3990099045/15735
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    题名: In vivo intelligent fluorescence endo-microscopy by varifocal meta-device and deep learning
    作者: Chia, YH;Liao, WH;Vyas, S;Chu, CH;Yamaguchi, T;Liu, XY;Tanaka, T;Huang, YY;Chen, MK;Chen, WS;Tsai, DP;Luo, Y
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Endo-microscopy is crucial for real-time 3D visualization of internal tissues and subcellular structures. Conventional methods rely on axial movement of optical components for precise focus adjustment, limiting miniaturization and complicating procedures. Meta-device, composed of artificial nanostructures, is an emerging optical flat device that can freely manipulate the phase and amplitude of light. Here, an intelligent fluorescence endo-microscope is developed based on varifocal meta-lens and deep learning (DL). The breakthrough enables in vivo 3D imaging of mouse brains, where varifocal meta-lens focal length adjusts through relative rotation angle. The system offers key advantages such as invariant magnification, a large field-of-view, and optical sectioning at a maximum focal length tuning range of approximate to 2 mm with 3 mu m lateral resolution. Using a DL network, image acquisition time and system complexity are significantly reduced, and in vivo high-resolution brain images of detailed vessels and surrounding perivascular space are clearly observed within 0.1 s (approximate to 50 times faster). The approach will benefit various surgical procedures, such as gastrointestinal biopsies, neural imaging, brain surgery, etc.
    日期: 2024-03-15
    關聯: Advanced Science. 2024 Mar 15;Article in Press.
    Link to: http://dx.doi.org/10.1002/advs.202307837
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2198-3844&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85187639769
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