國家衛生研究院 NHRI:Item 3990099045/15743
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    題名: Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters
    作者: Hsu, YT;Wu, CC;Wang, CC;Sheu, CC;Yang, YH;Cheng, MY;Lai, RS;Leung, SY;Lin, CC;Wei, YF;Lai, YF;Cheng, MH;Chen, HC;Yang, CJ;Wang, CJ;Liu, HJ;Chen, HL;Hung, CH;Lee, CL;Huang, MS;Huang, SK
    貢獻者: National Institute of Environmental Health Sciences;National Center for Geriatrics and Welfare Research;National Institute of Cancer Research
    摘要: BACKGROUND: DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant proportion of adult asthma cases are "non-atopic", lacking a clear etiology. METHODS: In a case-control study conducted between 2011 and 2015, 365 individuals with current asthma and 235 healthy controls from Kaohsiung City were enrolled. The control group comprised individuals without asthma, Type 2 Diabetes Mellitus (T2DM), hypertension, or other respiratory/allergic conditions. The study leveraged asthma clusters (Clusters A to F) established in a prior investigation. Analysis involved the examination of urinary DEHP metabolites (MEHP and MEHHP), along with the assessment of oxidative stress, sphingolipid metabolites, and inflammatory biomarkers. Statistical analyses encompassed Spearman's rank correlation coefficients, multiple logistic regression, and multinomial logistic regression. RESULTS: Asthma clusters (E, D, C, F, A) exhibited significantly higher ORs of MEHHP exposures compared to the control group. When considering asthma-related comorbidities (T2DM, hypertension, or both), patients without comorbidities demonstrated significantly higher ORs of the sum of primary and secondary metabolites (MEHP + MEHHP) and MEHHP compared to those with asthma comorbidities. A consistent positive correlation between urinary HEL and DEHP metabolites was observed, but a consistent negative correlation between DEHP metabolites and selected cytokines was identified. CONCLUSION: The current study reveals a heightened risk of MEHHP and MEHP + MEHHP exposure in specific asthma subgroups, emphasizing its complex relationship with asthma. The observed negative correlation with cytokines suggests a new avenue for research, warranting robust evidence from epidemiological and animal studies.
    日期: 2024-03-23
    關聯: Respiratory Research. 2024 Mar 23;25:Article number 139.
    Link to: http://dx.doi.org/10.1186/s12931-024-02764-8
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1465-993X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001189688800001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85188428899
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