國家衛生研究院 NHRI:Item 3990099045/15756
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    題名: Distinct protective effects of a novel Akkermansia sp. BCRC 18949 against DSS-Induced colitis in mice
    作者: Huang, CH;Huang, CT;Tsai, HY;Liao, YC;Lin, CM;Chen, PC;Liou, JS;Hsu, CL;Chiu, SH;Chen, CC;Hsieh, SY;Zou, HB;Hsu, CC;Chen, PS;Kao, CY;Ruan, JW
    貢獻者: Immunology Research Center;Institute of Population Health Sciences
    摘要: The emergence of next-generation probiotics (NGPs) has illuminated new possibilities for improving various diseases through food-grade supplements. In this study, a new gut bacterial species, designated as Akkermansia sp. BCRC 18949, was isolated from the feces of a healthy Taiwanese adult. The phylogenetic tree and whole genome sequencing analyses confirmed that this human commensal is a novel species belonging to the genus Akkermansia. Our results reveals that BCRC 18949 exhibits distinct mucin utilization abilities compared to ATCC BAA-835. Importantly, BCRC 18949 shows enhanced protection against DSS-induced colitis, while both species contribute differentially to restoring barrier integrity in DSS-treated mice. Furthermore, BCRC 18949 significantly restores the expression of colonic rhythmic genes, suggesting its potential role in maintaining circadian rhythm in the colon during colitis. Our findings provide valuable insights into the functional diversity of Akkermansia species and their potential therapeutic applications for colitis.
    日期: 2024-04
    關聯: Journal of Functional Foods. 2024 Apr;115:Article number 106110.
    Link to: http://dx.doi.org/10.1016/j.jff.2024.106110
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85187368774
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