國家衛生研究院 NHRI:Item 3990099045/15764

NHRI > National Institute of Environmental Health Sciences > Po-Chin Huang > Periodical Articles > Item 3990099045/15764

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15764

Title:	Highly electrochemically active Ti3C2Tx MXene/MWCNT nanocomposite for the simultaneous sensing of paracetamol, theophylline, and caffeine in human blood samples
Authors:	Mari, E;Duraisamy, M;Eswaran, M;Sellappan, S;Won, K;Chandra, P;Tsai, PC;Huang, PC;Chen, YH;Lin, YC;Ponnusamy, VK
Contributors:	National Institute of Environmental Health Sciences
Abstract:	The facile fabrication is reported of highly electrochemically active Ti3C2Tx MXene/MWCNT (3D/1D)-modified screen-printed carbon electrode (SPE) for the efficient simultaneous electrochemical detection of paracetamol, theophylline, and caffeine in human blood samples. 3D/1D Ti3C2Tx MXene/MWCNT nanocomposite was synthesized using microwave irradiation and ultrasonication processes. Then, the Ti3C2Tx/MWCNT-modified SPE electrode was fabricated and thoroughly characterized towards its physicochemical and electrochemical properties using XPS, TEM, FESEM, XRD, electrochemical impedance spectroscopy, cyclic voltammetry, and differential pulse voltammetry techniques. As-constructed Ti3C2Tx-MWCNT/SPE offers excellent electrochemical sensing performance with good detection limits (0.23, 0.57, and 0.43 µM) and wide linear ranges (1.0 ~ 90.1, 2.0 ~ 62.0, and 2.0–90.9 µM) for paracetamol, caffeine, and theophylline, respectively, in the human samples. Notably, the non-enzymatic electroactive nanocomposite-modified electrode has depicted a semicircle Nyquist plot with low charge transfer resistance (Rct∼95 Ω), leading to high ionic diffusion and facilitating an excellent electron transfer path. All the above results in efficient stability, reproducibility, repeatability, and sensitivity compared with other reported works, and thus, it claims its practical utilization in realistic clinical applications.
Date:	2024-03-20
Relation:	Microchimica Acta. 2024 Mar 20;191:Article number 212.
Link to:	http://dx.doi.org/10.1007/s00604-024-06273-9
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:001190584500001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85188230424
Appears in Collections:	[Po-Chin Huang] Periodical Articles

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