國家衛生研究院 NHRI:Item 3990099045/15773
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15773


    Title: Maternal folic acid supplementation during pregnancy in association with childhood overweight or obesity
    Authors: Hung, CY;Lee, HJ;Tsai, ZT;Huang, SJ;Huang, HY;Tsai, HJ;Yao, TC
    Contributors: Institute of Population Health Sciences
    Abstract: ObjectiveThis study aimed to examine associations of maternal folic acid supplementation (FAS) during pregnancy with childhood overweight or obesity (OWO) or adiposity.MethodsIn a population-based cohort of 1479 children, maternal FAS during pregnancy was assessed retrospectively by questionnaires. BMI and body fat percentages were measured at a mean age of 6.4 years. Pertinent factors were accounted for in data analyses.ResultsMaternal FAS during pregnancy was negatively associated with OWO (adjusted odds ratio: 0.70; 95% CI: 0.50 to 0.99). There were inverse associations of maternal FAS during pregnancy with BMI z score (beta: -0.22; 95% CI: -0.39 to -0.05), whole body fat percentage (beta: -1.28; 95% CI: -2.27 to -0.30), trunk fat percentage (beta: -1.41; 95% CI: -2.78 to -0.04), and limb fat percentage (beta: -1.31; 95% CI: -2.32 to -0.30). Stratified analyses found inverse associations of FAS during pregnancy with OWO, BMI z score, and body fat percentages predominantly among children without breastfeeding and whose parents had a below-tertiary educational level.ConclusionsThis study provides novel evidence that maternal FAS during pregnancy was significantly associated with a decreased risk of childhood OWO and adiposity, particularly among children with no breastfeeding and lower parental educational level.
    Date: 2024-04-04
    Relation: Obesity. 2024 Apr 04;Article in Press.
    Link to: http://dx.doi.org/10.1002/oby.24012
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1930-7381&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001196332600001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85189511414
    Appears in Collections:[Hui-Ju Tsai] Periodical Articles

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