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http://ir.nhri.org.tw/handle/3990099045/15806
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| Title: | Terminal deoxynucleotidyl transferase expression in different subtypes of childhood B-cell acute lymphoblastic leukemia |
| Authors: | Yu, CH;Su, YH;Jou, ST;Lu, MY;Lin, CY;Lin, KH;Chang, HH;Chou, SW;Huang, YH;Lin, DT;Lin, SW;Chen, HY;Chang, YH;Yang, YL |
| Contributors: | Institute of Molecular and Genomic Medicine |
| Abstract: | The lack of expression of terminal deoxynucleotidyl transferase (TdT) is frequently associated with KMT2A-rearranged subtype of pediatric acute lymphoblastic leukemia (ALL). However, this association has not been investigated extensively in the Asian population. A retrospective analysis of TdT expression in pediatric B-cell ALL (B-ALL) was performed in patients treated using the Taiwan Pediatric Oncology Group (TPOG) ALL 2002 and 2013 protocols. Among the 331 patients with B-ALL, 12 patients showed TdT negativity at initial diagnosis. Among these, eight patients showed KMT2A rearrangement (66.7%). Other patients showing negative TdT expression had ETV6::RUNX1, MEF2D-rearranged, and other B-ALL subtypes. However, in the context of KMT2A-rearranged B-ALL (n = 20), only eight patients showed TdT negativity. The 5-year event-free survival and overall survival of patients with and without TdT expression were 83.8% versus 46.8% (P <0.001) and 86.3% versus 55.4% (P = 0.004), respectively. Moreover, several aberrant markers, such as CD2, CD56, CD7, and CD117, were rarely expressed in the B-ALL samples, and if expressed, they were enriched in specific genetic subtypes. The results of this study indicate that immunophenotypic features are correlated with specific genetic subtypes of childhood B-ALL. |
| Date: | 2024-04 |
| Relation: | Pathology Research and Practice. 2024 Apr;256:Article number 155287. |
| Link to: | http://dx.doi.org/10.1016/j.prp.2024.155287 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0344-0338&DestApp=IC2JCR |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85189704177 |
| Appears in Collections: | [張雅媗] 期刊論文
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| SCP85189704177.pdf | | 1687Kb | Adobe PDF | 60 | View/Open |
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