國家衛生研究院 NHRI:Item 3990099045/15807
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    题名: Induction of petite colonies in Candida glabrate via rose bengal-mediated photodynamic therapy
    作者: Yang, CY;Hung, JH;Wu, CJ;Wang, ZX;Wang, SH;Liaw, HC;Lin, IH;Yu, CK;Wong, TW
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Facing a 40% mortality rate in candidemia patients, drug-resistant Candida and their petite mutants remain a major treatment challenge. Antimicrobial photodynamic therapy (aPDT) targets multiple fungal structures, unlike antibiotics/antifungals, potentially thwarting resistance. Traditional methods for inducing petite colonies rely on ethidium bromide or fluconazole, which can influence drug susceptibility and stress responses. This study investigated the application of green light (peak 520 nm) and rose bengal (RB) photosensitizer to combat a drug-resistant Candida glabrata isolate. The findings revealed that aPDT treatment significantly inhibited cell growth (≥99.9% reduction) and effectively induced petite colony formation, as evidenced by reduced size and loss of mitochondrial redox indicator staining. This study provides initial evidence that aPDT can induce petite colonies in a multidrug-resistant C. glabrata strain in vitro, offering a potentially transformative approach for combating resistant fungal infections.
    日期: 2024-03-29
    關聯: Journal of Visualized Experiments. 2024 Mar 29;2024(205):Article number e66549.
    Link to: http://dx.doi.org/10.3791/66549
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1940-087X&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85189900901
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