國家衛生研究院 NHRI:Item 3990099045/15841
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    题名: Alpha-lipoic acid ameliorates influenza A virus caused acute pneumonia though enhancement of anti-viral T cell immunity and suppression of macrophage activation by inhibiting ERK1/2 signaling pathway
    作者: Tsai, MW;Huang, SH;Chen, SJ;Ling, YC;Huang, JY;Jeng, PH;Chen, MF;Sytwu, HK;Lin, GJ
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: The first outbreak of influenza A virus (IAV), which has been circulating for many decades, has resulted in serious morbidity and mortality. The IAV epidemic has caused serious damage to human life and the economy. Following an IAV infection, lymphatic cells immediately enter the lungs to clear the virus and eliminate damaged cells to maintain normal physiological mechanisms. In this study, we used alpha-lipoic acid (ALA), which has versatile antioxidant functions, as a target to treat and evaluate host antiviral effects and immune mechanisms. We observed that pre-treatment with ALA improved the survival rate and pathological state in a mouse model. A reduction in the inflammatory cytokine tumor necrosis factor -alpha was observed following in vivo experiments. It also increased the release of antiviral cytokines into the lungs by T lymphocytes. ALA pre-treatment effectively prevented acute pneumonia by modulating immune composition and contributing to virus clearance.
    日期: 2024-05
    關聯: Journal of Functional Foods. 2024 May;116:Article number 106212.
    Link to: http://dx.doi.org/10.1016/j.jff.2024.106212
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1756-4646&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001223598900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85191300136
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