國家衛生研究院 NHRI:Item 3990099045/15842
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    题名: The edifice of vasculature-on-chips: A focused review on the key elements and assembly of angiogenesis models
    作者: Lim, J;Fang, HW;Bupphathong, S;Sung, PC;Yeh, CE;Huang, W;Lin, CH
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: The conception of vascularized organ-on-a-chip models provides researchers with the ability to supply controlled biological and physical cues that simulate the in vivo dynamic microphysiological environment of native blood vessels. The intention of this niche research area is to improve our understanding of the role of the vasculature in health or disease progression in vitro by allowing researchers to monitor angiogenic responses and cell-cell or cell-matrix interactions in real time. This review offers a comprehensive overview of the essential elements, including cells, biomaterials, microenvironmental factors, microfluidic chip design, and standard validation procedures that currently govern angiogenesis-on-a-chip assemblies. In addition, we emphasize the importance of incorporating a microvasculature component into organ-on-chip devices in critical biomedical research areas, such as tissue engineering, drug discovery, and disease modeling. Ultimately, advances in this area of research could provide innovative solutions and a personalized approach to ongoing medical challenges.
    日期: 2024-05-07
    關聯: ACS Biomaterials Science and Engineering. 2024 May 07;Article in Press.
    Link to: http://dx.doi.org/10.1021/acsbiomaterials.3c01978
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2373-9878&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001225087200001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85192831385
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