國家衛生研究院 NHRI:Item 3990099045/15847
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15847


    Title: Biodegradable hafnium-doped CaCO3 nanoparticles as a dual-modality radiosensitizer for cancer radiotherapy
    Authors: Chen, MH;Zeng, XH;Shu, YT;Liang, HK;Chen, CY;Lin, CY;Lin, CAJ;Chen, JK
    Contributors: Institute of Biomedical Engineering and Nanomedicine
    Abstract: Aim: Radiotherapy employs high-energy ionizing radiation to inflict DNA damage on cancer cells, thereby causing their demise. However, this procedure can inadvertently harm healthy tissue. Thus, this study aimed to develop biodegradable radiosensitizers that counteract these adverse effects by enhancing the radiation sensitivity of tumor cells and safeguarding normal cells. Materials & methods: A biodegradable radiosensitizer was engineered by incorporating hafnium ions (Hf) into calcium carbonate (CaCO3) nanoparticles via a chemical precipitation technique, resulting in the formation of Hf:CaCO3 nanoparticles. Results & conclusion: Our findings demonstrate that Hf:CaCO3 nanoparticles exhibit pH-dependent solubility and can augment the efficacy of radiotherapy in treating cancer cells. This research underscores the potential of Hf:CaCO3 nanoparticles as a dual-modality radiosensitizer in radiotherapy.
    Date: 2024-05
    Relation: Nanomedicine: Nanotechnology, Biology, and Medicine. 2024 May;Article in Press.
    Link to: http://dx.doi.org/10.1080/17435889.2024.2343275
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1743-5889&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001229115800001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85193620916
    Appears in Collections:[Jen-Kun Chen] Periodical Articles

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