國家衛生研究院 NHRI:Item 3990099045/15849
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    國家衛生研究院 NHRI > 癌症研究所 > 其他 > 期刊論文 >  Item 3990099045/15849


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    题名: High PGC-1alpha expression as a poor prognostic indicator in intracranial glioma
    其它题名: High PGC-1α expression as a poor prognostic indicator in intracranial glioma
    作者: Cheng, YW;Lee, JH;Chang, CH;Tseng, TT;Chai, CY;Lieu, AS;Kwan, AL
    贡献者: National Institute of Cancer Research
    摘要: Gliomas are the most common primary brain tumors in adults. Despite multidisciplinary treatment approaches, the survival rates for patients with malignant glioma have only improved marginally, and few prognostic biomarkers have been identified. Peroxisome proliferator-activated receptor gamma (PPAR gamma) coactivator-1 alpha (PGC-1 alpha) is a crucial regulator of cancer metabolism, playing a vital role in cancer cell adaptation to fluctuating energy demands. In this study, the clinicopathological roles of PGC-1 alpha in gliomas were evaluated. Employing immunohistochemistry, cell culture, siRNA transfection, cell viability assays, western blot analyses, and in vitro and in vivo invasion and migration assays, we explored the functions of PGC-1 alpha in glioma progression. High PGC-1 alpha expression was significantly associated with an advanced pathological stage in patients with glioma and with poorer overall survival. The downregulation of PGC-1 alpha inhibited glioma cell proliferation, invasion, and migration and altered the expression of oncogenic markers. These results conclusively demonstrated that PGC-1 alpha plays a critical role in maintaining the malignant phenotype of glioma cells and indicated that targeting PGC-1 alpha could be an effective strategy to curb glioma progression and improve patient survival outcomes.
    日期: 2024-04-29
    關聯: Biomedicines. 2024 Apr 29;12(5):Article number 979.
    Link to: http://dx.doi.org/10.3390/biomedicines12050979
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2227-9059&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001232421100001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85194094072
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