國家衛生研究院 NHRI:Item 3990099045/15861
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15861


    Title: Sputum bacterial microbiota signature as a surrogate for predicting disease progression of nontuberculous mycobacterial lung disease
    Authors: Huang, HL;Lin, CH;Lee, MR;Huang, WC;Sheu, CC;Cheng, MH;Lu, PL;Huang, CH;Yeh, YT;Yang, JM;Chong, IW;Liao, YC;Wang, JY
    Contributors: Institute of Population Health Sciences
    Abstract: OBJECTIVES: Predicting progression of nontuberculous mycobacterial lung disease (NTM-LD) remains challenging. This study evaluated whether sputum bacterial microbiome diversity can be the biomarker and provide novel insights into related phenotypes and treatment timing. METHODS: We analyzed 126 sputum microbiomes of 126 patients with newly diagnosed NTM-LD due to Mycobacterium avium complex, M. abscessus complex, and M. kansasii between May 2020 and December 2021. Patients were followed for 2 years to determine their disease progression status. We identified consistently representative genera that differentiated the progressor and nonprogressor by using six methodologies. These genera were used to construct a prediction model using random forest with 5-fold cross validation. RESULTS: Disease progression occurred in 49 (38.6%) patients. Compared with nonprogressors, α-diversity was lower in the progressors. Significant compositional differences existed in the β-diversity between groups (p=0.001). The prediction model for NTM-LD progression constructed using seven genera (Burkholderia, Pseudomonas, Sphingomonas, Candidatus Saccharibacteria, Phocaeicola, Pelomonas, and Phascolarctobacterium) with significantly differential abundance achieved an area under curve of 0.871. CONCLUSIONS: Identification of the composition of sputum bacterial microbiome facilitates prediction of the course of NTM-LD, and maybe used to develop precision treatment involving modulating the respiratory microbiome composition to ameliorate NTM-LD.
    Date: 2024-05-11
    Relation: International Journal of Infectious Diseases. 2024 May 11;Article in Press.
    Link to: http://dx.doi.org/10.1016/j.ijid.2024.107085
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1201-9712&DestApp=IC2JCR
    Appears in Collections:[Yu-Chieh Liao] Periodical Articles

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