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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/15946


    Title: Topiramate suppresses peri-infarct spreading depolarization and improves outcomes in a rat model of photothrombotic stroke
    Authors: Wang, Y;Yen, S;Ian Shih, YY;Lai, CW;Chen, YL;Chen, LT;Chen, H;Liao, LD
    Contributors: Institute of Biomedical Engineering and Nanomedicine;National Institute of Cancer Research
    Abstract: Ischemic stroke can cause depolarized brain waves, termed peri-infarct depolarization (PID). Here, we evaluated whether topiramate, a neuroprotective drug used to treat epilepsy and alleviate migraine, has the potential to reduce PID. We employed a rat model of photothrombotic ischemia that can reliably and reproducibly induce PID and developed a combined electrocorticography-laser speckle contrast imaging (ECoG-LSCI) platform to monitor neuronal activity and cerebral blood flow (CBF) simultaneously. Topiramate administration after photothrombotic ischemia did not rescue CBF but significantly restored somatosensory evoked potentials in the forelimb area of the primary somatosensory cortex. Moreover, infarct volume was investigated by 2,3,5-triphenyltetrazolium chloride (TTC) staining, and neuronal survival was evaluated by Nissl staining. Mechanistically, the levels of inflammatory markers, such as ED1 (CD68), Iba-1, and GFAP, decreased significantly after topiramate administration, as did BDNF expression, while the expression of NeuN and Bcl-2/Bax increased, which is indicative of reduced inflammation and improved neuroprotection.
    Date: 2024-06-21
    Relation: iScience. 2024 Jun 21;27(6):Article number 110033.
    Link to: http://dx.doi.org/10.1016/j.isci.2024.110033
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2589-0042&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001257669500001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85195098733
    Appears in Collections:[廖倫德] 期刊論文
    [陳立宗] 期刊論文

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