國家衛生研究院 NHRI:Item 3990099045/15979
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    題名: Yearly change in air pollution and brain aging among older adults: A community-based study in Taiwan
    作者: Lin, YC;Fan, KC;Wu, CD;Pan, WC;Chen, JC;Chao, YP;Lai, YJ;Chiu, YL;Chuang, YF
    貢獻者: National Institute of Environmental Health Sciences
    摘要: Background: Air pollution is recognized as a modifiable risk factor for dementia, and recent evidence suggests that improving air quality could attenuate cognitive decline and reduce dementia risk. However, studies have yet to explore the effects of improved air quality on brain structures. This study aims to investigate the impact of air pollution reduction on cognitive functions and structural brain differences among cognitively normal older adults. Methods: Four hundred and thirty-one cognitively normal older adults were from the Epidemiology of Mild Cognitive Impairment study in Taiwan (EMCIT), a community-based cohort of adults aged 60 and older, between year 2017 - 2021. Annual concentrations of PM 2.5 , NO 2 , O 3 , and PM 10 at participants ' residential addresses during the 10 years before enrollment were estimated using ensemble mixed spatial models. The yearly rate of change (slope) in air pollutants was estimated for each participant. Cognitive functions and structural brain images were collected during enrollment. The relationships between the rate of air pollution change and cognitive functions were examined using linear regression models. For air pollutants with significant findings in relation to cognitive function, we further explored the association with brain structure. Results: Overall, all pollutant concentrations, except O 3 , decreased over the 10-year period. The yearly rates of change (slopes) in PM 2.5 and NO 2 were correlated with better attention (PM 2.5 : r =-0.1, p = 0.047; NO 2 : r =-0.1, p = 0.03) and higher white matter integrity in several brain regions. These regions included anterior thalamic radiation, superior longitudinal fasciculus, inferior longitudinal fasciculus, corticospinal tract, and inferior fronto-occipital fasciculus. Conclusions: Greater rate of reduction in air pollution was associated with better attention and attention-related white matter integrity. These results provide insight into the mechanism underlying the relationship between air pollution, brain health, and cognitive aging among older adults.
    日期: 2024-08
    關聯: Environment International. 2024 Aug;190:Article number 108876.
    Link to: http://dx.doi.org/10.1016/j.envint.2024.108876
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0160-4120&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001271517400001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85198318590
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