國家衛生研究院 NHRI:Item 3990099045/16104
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/16104


    Title: Microvascular disease and its association with dementia in patients with type 2 diabetes: A nationwide cohort study in Taiwan
    Authors: Yen, YH;Yen, FS;Ko, FS;Wei, JCC;Huang, YH;Yu, TS;Hwu, CM;Hsu, CC
    Contributors: Institute of Population Health Sciences;National Center for Geriatrics and Welfare Research
    Abstract: Aim: To assess the likelihood of dementia in individuals with type 2 diabetes (T2D), distinguishing between those with and without microvascular diseases. Methods: Leveraging the National Health Insurance Research Database in Taiwan, we identified individuals newly diagnosed with T2D from 1 January 2009 through 31 December 2014. Multivariable Cox proportional hazard models were used to compare the risk of outcomes. Results: Individuals with microvascular disease had a significantly higher risk of all-cause dementia (adjusted hazard ratio [95% confidence interval] 1.13 [1.09, 1.17]) compared with matched individuals without microvascular disease. In addition, individuals with diabetic kidney disease and diabetic neuropathy were associated with a significantly increased risk of Alzheimer's disease (1.16 [1.02, 1.32] and 1.14 [1.03, 1.27]), vascular dementia (1.21 [1.06, 1.38] and 1.14 [1.02, 1.28]) and other dementia (1.11 [1.04, 1.19] and 1.10 [1.04, 1.16]), respectively, compared with those without microvascular disease. Conclusions: This nationwide cohort study showed that patients with T2D and microvascular disease, particularly diabetic kidney disease and diabetic neuropathy, were associated with a significantly higher risk of Alzheimer's disease, vascular dementia, other dementia and all-cause dementia than those without microvascular disease.
    Date: 2024-08-29
    Relation: Diabetes Obesity and Metabolism. 2024 Aug 29;26(11):5399-5407.
    Link to: http://dx.doi.org/10.1111/dom.15908
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1462-8902&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001301188400001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85202857271
    Appears in Collections:[Chih-Cheng Hsu] Periodical Articles
    [Chih-Cheng Hsu] Periodical Articles

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