國家衛生研究院 NHRI:Item 3990099045/16108
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    題名: Monacolin-K loaded MIL-100(Fe) metal-organic framework induces ferroptosis on metastatic triple-negative breast cancer
    作者: Yu, CH;Hermosa, GC;Sun, AC;Wu, CWK;Gao, MT;Wu, C;Wang, HMD
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Breast cancer is the most common disease among women worldwide. Triple-negative breast cancer (TNBC) is the most aggressive and has the worst prognosis. MIL-100(Fe) is a promising metal-organic framework (MOF). MIL100(Fe) was loaded with monacolin K (MK) to form MK@MIL-100(Fe). MK was a natural compound with anticancer properties. The surface of MK@MIL-100(Fe) was coated with iron oxide (Fe3O4), 3 O 4 ), and the microwave hydrothermal method was used to form the material MK@MIL-100(Fe)/Fe3O4 3 O 4 with metal-organic properties, which effectively increases the accumulation of reactive oxygen species and lipids in cancer cells. In the mouse model of metastatic TNBC formed by tail vein injection of 4 T1 cells, MK@MIL-100(Fe)/Fe3O4 3 O 4 inhibited the occurrence of metastatic TNBC without hair shedding, and no side effects were found. In cell and mouse experiments, expressions of ferroptosis-related proteins, glutathione peroxidase (GPX4), and 3-hydroxy-3-methylglutaryl-coA reductase (HMGCR) were reduced. Apoptotic regulatory factors were increased, as BH3 interacting- domain death agonist (BID), apoptosis-inducing factor (AIF), endonuclease G (Endo-G), bcl2-associated X protein (BAX) and caspase-3 (Casp3). Therefore, we demonstrated that the MOF has been functionalized to enhance its biocompatibility and iron targeting ability, and MK@MIL-100(Fe)/Fe3O4 3 O 4 served as a nanomedicine to inhibit TNBC through ferroptosis and apoptosis.
    日期: 2024-10-15
    關聯: Chemical Engineering Journal. 2024 Oct 15;498:Article number 154751.
    Link to: http://dx.doi.org/10.1016/j.cej.2024.154751
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1385-8947&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001304145000001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85202352567
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