國家衛生研究院 NHRI:Item 3990099045/16111
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    题名: BRCA genetic testing and counseling in breast cancer: How do we meet our patients' needs?
    作者: Dubsky, P;Jackisch, C;Im, SA;Hunt, KK;Li, CF;Unger, S;Paluch-Shimon, S
    贡献者: National Institute of Cancer Research
    摘要: BRCA1 and BRCA2 are tumor suppressor genes that have been linked to inherited susceptibility of breast cancer. Germline BRCA1/2 pathogenic or likely pathogenic variants (gBRCAm) are clinically relevant for treatment selection in breast cancer because they confer sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors. BRCA1/2 mutation status may also impact decisions on other systemic therapies, risk-reducing measures, and choice of surgery. Consequently, demand for gBRCAm testing has increased. Several barriers to genetic testing exist, including limited access to testing facilities, trained counselors, and psychosocial support, as well as the financial burden of testing. Here, we describe current implications of gBRCAm testing for patients with breast cancer, summarize current approaches to gBRCAm testing, provide potential solutions to support wider adoption of mainstreaming testing practices, and consider future directions of testing.
    日期: 2024-09-05
    關聯: npj Breast Cancer. 2024 Sep 05;10:Article number 77.
    Link to: http://dx.doi.org/10.1038/s41523-024-00686-8
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2374-4677&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:001306401900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85203294303
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